Carter K C, Wang L, Shell B K, Zamir I, Berger S L, Moore P A
Department of Molecular Biology, Human Genome Sciences, 9410 Key West Avenue, Rockville, Maryland 20850-3331, USA.
Genomics. 1997 Mar 15;40(3):497-500. doi: 10.1006/geno.1996.4605.
The chromosomal locations and the tissue expression patterns of the human transcriptional adaptors TADA2L and GCN5L2 have been determined. Northern blot analysis across a range of human tissues revealed that both the TADA2L and the GCN5L2 mRNAs are expressed to varying degrees in all tissue types. Furthermore, in most tissue types, the genes are expressed at relatively similar levels, suggesting coordinated regulation of TADA2L and GCN5L2 transcription. Chromosomal mapping by fluorescence in situ hybridization indicated that these genes reside near each other on chromosome 17; TADA2L mapped within bands 17q12-q21, while GCN5L2 mapped distally within band 17q21.
人类转录衔接子TADA2L和GCN5L2的染色体定位及组织表达模式已被确定。对一系列人类组织进行的Northern印迹分析表明，TADA2L和GCN5L2的mRNA在所有组织类型中均有不同程度的表达。此外，在大多数组织类型中，这两个基因的表达水平相对相似，表明TADA2L和GCN5L2转录存在协同调控。荧光原位杂交染色体定位表明，这些基因在17号染色体上彼此相邻；TADA2L定位于17q12 - q21带内，而GCN5L2定位于17q21带的远端。
