Ottoboni A, Bissell G D, Hexter A C
Arch Environ Contam Toxicol. 1977;6(1):83-101. doi: 10.1007/BF02097752.
The effects of chronic oral exposure to 1, 5, and 10 mg of technical DDT/kg/day on: 1) age at puberty, length of gestation, fertility, success of pregnancy, litter size, and lactational ability of dams; 2) viability, survival to weaning, sex distribution and growth of pups; and 3) morbidity, mortality, organ/body weight ratios, gross and histologic abnormalities in all animals were studied through three generations of Beagle dogs. There were a total of 135 adult female and 63 adult male dogs in the project which produced 650 pups. There were no statistically significant differences among control and DDT-treated dogs in any of the reproductive variables, with the exception of age at puberty of the females. DDT-treated females had their first estrous cycles 2 to 3 months earlier (P less than .001) than the control dogs. Selected DDT-treated females, held for a second breeding period, had normal anestrous periods between their first and second estrous cycles. There was no effect of DDT on survival, growth, and sex distribution of pups, nor was there any influence on morbidity, mortality, gross or histologic findings in any of the dogs. All organ/body weight ratios were normal, with the possible exception of an increase in liver/body weight ratio in some DDT-treated animals.
通过三代比格犬研究了每天每千克体重经口慢性暴露于1毫克、5毫克和10毫克工业用滴滴涕（DDT）对以下方面的影响：1）青春期年龄、妊娠期长度、生育力、妊娠成功率、窝仔数以及母犬的泌乳能力；2）幼犬的活力、存活至断奶情况、性别分布和生长；3）所有动物的发病率、死亡率、器官/体重比、大体和组织学异常。该项目共有135只成年雌性犬和63只成年雄性犬，共产下650只幼犬。除雌性青春期年龄外，对照组和DDT处理组犬在任何生殖变量上均无统计学显著差异。DDT处理的雌性犬比对照犬提前2至3个月进入首次发情周期（P小于0.001）。选择接受DDT处理的雌性犬进行第二个繁殖期，其在首次和第二次发情周期之间有正常的乏情期。DDT对幼犬的存活、生长和性别分布没有影响，对任何犬的发病率、死亡率、大体或组织学结果也没有影响。所有器官/体重比均正常，部分接受DDT处理的动物肝脏/体重比可能有所增加除外。
