Chen C J, Vandenbergh J G
Department of Zoology, North Carolina State University, Raleigh 27695-7617.
Pharmacol Biochem Behav. 1994 Aug;48(4):909-13. doi: 10.1016/0091-3057(94)90199-6.
The effect of chronic cocaine exposure on the reproductive success of juvenile female house mice was studied. We followed two generations of female mice to examine the consequence of cocaine treatment on developmental and reproductive parameters such as weight gain, first estrus, impregnation, fertility, and maternal success. Twenty-two-day-old female mice were given cocaine at a daily total of 40 mg/kg body weight, delivered by two SC injections of 20 mg/kg each, until they were mated and inseminated by experienced males. The treatment attenuated weight gain and delayed puberty in the females but had no discernible effect on their pups. Administration of cocaine to lactating mothers decreased the weaning weight of their pups. Juvenile females previously nursed by mothers receiving cocaine and receiving 40 mg/kg cocaine daily themselves were impregnated at older ages than controls. Nevertheless, once these juveniles reached puberty, they mated successfully and their reproductive parameters did not differ from those of control mice. Thus, chronic cocaine treatment of juvenile female mice slows body growth and development but has little effect on the offspring produced later when they reached adulthood.
研究了长期接触可卡因对幼年雌性家鼠繁殖成功率的影响。我们跟踪了两代雌性小鼠，以检查可卡因处理对发育和生殖参数的影响，如体重增加、首次发情、受孕、生育能力和母性成功率。给22日龄的雌性小鼠每天注射总量为40 mg/kg体重的可卡因，通过两次皮下注射，每次20 mg/kg，直到它们与经验丰富的雄性小鼠交配并受精。该处理使雌性小鼠体重增加减缓，青春期延迟，但对其幼崽没有明显影响。给哺乳期的母亲注射可卡因会降低其幼崽的断奶体重。以前由接受可卡因的母亲哺乳且自己每天接受40 mg/kg可卡因的幼年雌性小鼠，受孕年龄比对照组大。然而，一旦这些幼崽达到青春期，它们就能成功交配，其生殖参数与对照小鼠没有差异。因此，对幼年雌性小鼠进行长期可卡因处理会减缓身体生长和发育，但对它们成年后产生的后代影响很小。
