Schmeling W T, Hosko M J
Arch Int Pharmacodyn Ther. 1977 Jun;227(2):302-8.
Pretreatment of rats with 6-hydroxydopamine over a narrow dose range (100 mg/kg i.p.), attenuated the hypothermic response elicited by administration of delta9-tetrahydrocannabinol (delta9-THC) (10 mg/kg i.p.). Pretreatment with hexamethonium (10 mg/kg i.p.) also attenuated the response. These findings suggest that the hypothermic response produced by delta9-THC administration in the rat is related to alteration of autonomic outflow.
在狭窄剂量范围内（腹腔注射100毫克/千克）用6-羟基多巴胺预处理大鼠，可减弱腹腔注射δ9-四氢大麻酚（δ9-THC，10毫克/千克）引起的体温过低反应。用六甲铵（腹腔注射10毫克/千克）预处理也可减弱该反应。这些发现表明，大鼠腹腔注射δ9-THC所产生的体温过低反应与自主神经输出的改变有关。
