δ9-四氢大麻酚诱导的大鼠体温过低的阻断作用。
Blockade of delta9-thc induced hypothermia in rats.
作者信息
Schmeling W T, Hosko M J
出版信息
Arch Int Pharmacodyn Ther. 1977 Jun;227(2):302-8.
PMID:907415
Abstract
Pretreatment of rats with 6-hydroxydopamine over a narrow dose range (100 mg/kg i.p.), attenuated the hypothermic response elicited by administration of delta9-tetrahydrocannabinol (delta9-THC) (10 mg/kg i.p.). Pretreatment with hexamethonium (10 mg/kg i.p.) also attenuated the response. These findings suggest that the hypothermic response produced by delta9-THC administration in the rat is related to alteration of autonomic outflow.
摘要
在狭窄剂量范围内（腹腔注射100毫克/千克）用6-羟基多巴胺预处理大鼠，可减弱腹腔注射δ9-四氢大麻酚（δ9-THC，10毫克/千克）引起的体温过低反应。用六甲铵（腹腔注射10毫克/千克）预处理也可减弱该反应。这些发现表明，大鼠腹腔注射δ9-THC所产生的体温过低反应与自主神经输出的改变有关。
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