Haavik C O
Fed Proc. 1977 Nov;36(12):2595-8.
The tetrahydrocannabinols are among the most potent hypothermic agents known. A comparison of the hypothermic action of delta9-tetrahydrocannabinol (delta9-THC) with chlorpromazine (CPZ) and morphine shows the following order of hypothermic potency: CPZ greater than delta9-THC greater than morphine. A marked depression of oxygen consumption is produced by delta9-THC both in vivo and in the isolated perfused liver preparation. Simultaneous measurement of core temperature and tail temperature after delta9-THC shows that tail temperature is decreased more by delta9-THC than it is in animals that attain comparable core hypothermia without drug treatment. From these results, it is concluded that delta9-THC-induced hypothermia results primarily from decreased heat production and not from increased heat loss. Therefore, the processes involved in the hypothermic response to delta9-THC appear to differ from those that mediate CPZ- or morphine-induced hypothermia. A hypothesis is discussed in which the hypothermic action of delta9-THC is related to inhibition of membrane ATPase.
四氢大麻酚是已知最强效的体温降低剂之一。将δ9 - 四氢大麻酚（δ9 - THC）与氯丙嗪（CPZ）和吗啡的体温降低作用进行比较，结果显示体温降低效力顺序如下：CPZ＞δ9 - THC＞吗啡。δ9 - THC在体内和离体灌注肝脏制剂中均会导致氧消耗显著降低。在给予δ9 - THC后同时测量核心体温和尾部体温，结果表明，与未经药物治疗而达到类似核心体温降低的动物相比，δ9 - THC使尾部体温降低得更多。从这些结果可以得出结论，δ9 - THC诱导的体温降低主要是由于产热减少，而非散热增加。因此，对δ9 - THC体温降低反应所涉及的过程似乎与介导CPZ或吗啡诱导体温降低的过程不同。本文讨论了一个假说，即δ9 - THC的体温降低作用与膜ATP酶的抑制有关。
