Esen F, Celebi G, Ertekin C, Colakoglu Z
Department of Biophysics, Ege University School of Medicine, Bornova, Izmir, Turkey.
Clin Auton Res. 1997 Feb;7(1):35-40. doi: 10.1007/BF02267624.
Peripheral sympathetic activity was investigated in 25 Parkinson's disease (PD) patients and 27 healthy subjects by measuring the skin resistance level (SRL) and skin resistance response (SRR) at the palm of the hand during rest, auditory stimulation and patellar tendon tapping. Blood flow to the hand was also monitored. Normal responses were obtained from all the 27 healthy subjects with both stimuli. All but one of the 25 PD patients responded to sound, six patients failed to respond to patellar tendon tapping and one patient failed to respond to both stimuli. The SRRs (when detectable) of PD patients were always smaller in amplitude than those of normal subjects. It was also observed that while an electrodermal response was present, no vasomotor response could be elicited by either stimulus in some patients. The opposite was true in some other patients. When response latencies were evaluated, it was found that although the mean latency of SRRs evoked by tendon taping was shorter than the mean latency of responses to auditory stimuli in normal subjects, this was not the case in PD patients. SRR mean latency to patellar tendon tapping was significantly longer in PD patients compared with that in normal subjects. Mean latencies of responses to auditory stimuli were the same for both normal subjects and patients. The ratio of the SRR amplitude to SRL (i.e. relative change in SRL) during both types of stimulation was significantly smaller in PD patients than in normal subjects. All the above findings were also true when blood flow to the tissue was interrupted briefly. These findings support the conjecture that the abnormal peripheral sympathetic neural responses associated with PD may arise from a functional disorder in the basal ganglia that influence the efferent autonomic pathway, from impairment of the intermediolateral column of the spinal cord, and possibly from cognitive deficits.
通过测量25名帕金森病（PD）患者和27名健康受试者在休息、听觉刺激和髌腱叩击时手掌的皮肤电阻水平（SRL）和皮肤电阻反应（SRR），对其外周交感神经活动进行了研究。同时也监测了手部的血流情况。27名健康受试者对两种刺激均获得了正常反应。25名PD患者中除1名外对声音有反应，6名患者对髌腱叩击无反应，1名患者对两种刺激均无反应。PD患者的SRRs（当可检测到时）幅度总是小于正常受试者。还观察到，虽然存在皮肤电反应，但在一些患者中，两种刺激均未引发血管运动反应。在其他一些患者中则相反。当评估反应潜伏期时，发现虽然在正常受试者中，髌腱叩击诱发的SRRs平均潜伏期短于对听觉刺激的反应平均潜伏期，但在PD患者中并非如此。与正常受试者相比，PD患者对髌腱叩击的SRR平均潜伏期明显更长。正常受试者和患者对听觉刺激的反应平均潜伏期相同。在两种刺激期间，PD患者的SRR幅度与SRL的比值（即SRL的相对变化）明显小于正常受试者。当短暂中断组织血流时，上述所有发现仍然成立。这些发现支持了这样的推测，即与PD相关的外周交感神经异常反应可能源于基底神经节影响自主传出通路的功能障碍、脊髓中间外侧柱的损伤，也可能源于认知缺陷。
