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正常对照受试者和帕金森病受试者敲击速度的决定因素:短期和持续练习的不同影响。

Determinants of tapping speed in normal control subjects and subjects with Parkinson's disease: differing effects of brief and continued practice.

作者信息

Nutt J G, Lea E S, Van Houten L, Schuff R A, Sexton G J

机构信息

Department of Neurology, and Physiology and Pharmacology, General Clinical Research Center, School of Medicine, Oregon Health Sciences University, Portland 97201-3098, USA.

出版信息

Mov Disord. 2000 Sep;15(5):843-9. doi: 10.1002/1531-8257(200009)15:5<843::aid-mds1013>3.0.co;2-2.

Abstract

BACKGROUND

Alternate tapping speed is widely used as a measure of bradykinesia in Parkinson's disease (PD). Tapping speed in normal control subjects and factors that might influence tapping speed have not been systematically examined.

OBJECTIVE

To examine the effects of age, hand dominance, and gender on tapping speed in normal control subjects and to compare the effects of practice on tapping speed in normal and PD control subjects.

METHODS

Tapping speed for three sequential trials in the dominant and nondominant hand was examined in 100 normal control subjects and 60 subjects with PD. The effect of hourly practice over 26 hours (19 trials) was investigated in 14 normal and 24 PD subjects.

RESULTS

The speed with which normal subjects alternately tapped two counters was negatively correlated with age, was greater in the dominant hand, was not related to gender, and improved with short-term practice (three trials) and with continued practice over 26 hours. Parkinsonian subjects, in general, tapped more slowly than normal control subjects and more slowly in the more affected arm. Parkinsonian subjects benefited from short-term practice as much as normal control subjects but, unlike normal control subjects, did not improve with continued practice over 26 hours.

CONCLUSIONS

Alternate tapping speed is influenced by age, hand dominance, Parkinson's disease, and practice. Subjects with PD do not benefit as much from continued practice as do normal subjects, suggesting some limitation or impairment of procedural (motor) learning in PD.

摘要

背景

交替敲击速度被广泛用作帕金森病(PD)运动迟缓的一项指标。正常对照受试者的敲击速度以及可能影响敲击速度的因素尚未得到系统研究。

目的

研究年龄、利手和性别对正常对照受试者敲击速度的影响,并比较练习对正常对照受试者和PD受试者敲击速度的影响。

方法

对100名正常对照受试者和60名PD受试者的优势手和非优势手进行三次连续试验的敲击速度检测。对14名正常受试者和24名PD受试者进行了26小时(19次试验)的每小时练习效果研究。

结果

正常受试者交替敲击两个计数器的速度与年龄呈负相关,优势手的敲击速度更快,与性别无关,短期练习(三次试验)及26小时的持续练习后速度提高。一般而言,帕金森病受试者的敲击速度比正常对照受试者慢,在受影响更严重的手臂上敲击速度更慢。帕金森病受试者从短期练习中获得的益处与正常对照受试者一样多,但与正常对照受试者不同的是,在26小时的持续练习后并未改善。

结论

交替敲击速度受年龄、利手、帕金森病和练习的影响。PD受试者从持续练习中获得的益处不如正常受试者多,这表明PD患者在程序性(运动)学习方面存在一些限制或损害。

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