牛基因组的第二代连锁图谱。

A second-generation linkage map of the bovine genome.

作者信息

Kappes S M, Keele J W, Stone R T, McGraw R A, Sonstegard T S, Smith T P, Lopez-Corrales N L, Beattie C W

机构信息

U.S. Department of Agriculture (USDA), Agricultural Research Service (ARS), U.S. Meat Animal Research Center, Clay Center, Nebraska 68933-0166, USA.

出版信息

Genome Res. 1997 Mar;7(3):235-49. doi: 10.1101/gr.7.3.235.

DOI:10.1101/gr.7.3.235

PMID:9074927

Abstract

We report a bovine linkage map constructed with 1236 polymorphic DNA markers and 14 erythrocyte antigens and serum proteins. The 2990-cM map consists of a sex-specific, X chromosome linkage group and 29 sex-averaged, autosomal linkage groups with an average interval size of 2.5 cM. The map contains 627 new markers and 623 previously linked markers, providing a basis for integrating the four published bovine maps. Orientation and chromosomal assignment of all the linkage groups, except BTA20 and BTA22, was provided by 88 markers that were assigned previously to chromosomes. This map provides sufficient marker density for genomic scans of populations segregating quantitative trait loci (QTL) and subsequent implementation of marker-assisted selection (MAS) mating schemes.

摘要

我们报告了一张牛的连锁图谱，该图谱由1236个多态性DNA标记以及14种红细胞抗原和血清蛋白构建而成。这张2990厘摩的图谱包括一个性特异性的X染色体连锁群和29个性平均的常染色体连锁群，平均间隔大小为2.5厘摩。该图谱包含627个新标记和623个先前已连锁的标记，为整合已发表的四张牛图谱提供了基础。除BTA20和BTA22外，所有连锁群的定位和染色体分配均由先前已定位到染色体上的88个标记提供。此图谱为分离数量性状基因座（QTL）的群体进行基因组扫描以及随后实施标记辅助选择（MAS）交配方案提供了足够的标记密度。