Ashman R B, Fulurija A, Papadimitriou J M
Pathology Department, University of Western Australia, Nedlands, Australia.
Microb Pathog. 1997 Mar;22(3):187-92. doi: 10.1006/mpat.1996.0102.
Tissue damage in the kidney and brain after systemic infection with Candida albicans was examined in recombinant inbred strains (AKXL) derived from AKR and C57/L progenitors. Nine of the 15 strains showed mild (C57/L-like) tissue damage. Of the remainder, two strains developed lesions comparable to the AKR parental strain, whereas four exhibited a much more severe pattern of tissue damage. This was characterized by pronounced mycelial growth in the brain, and gross oedema of the kidney, with extensive fungal colonization and marked tissue destruction. The presence of the null allele of the haemolytic complement gene (Hc) may be necessary, but not sufficient, for the expression of the very severe lesions. The results were interpreted as reflecting the actions of two independent genes, which have been designated Carg1 and Carg2 (Candida albicans resistance genes 1 and 2).
在源自AKR和C57/L祖系的重组近交系（AKXL）中，研究了白色念珠菌全身感染后肾脏和大脑的组织损伤情况。15个品系中有9个表现出轻度（C57/L样）组织损伤。其余品系中，两个品系出现的损伤与AKR亲本品系相当，而另外四个品系则表现出更为严重的组织损伤模式。其特征为大脑中菌丝显著生长，肾脏出现严重水肿，伴有广泛的真菌定植和明显的组织破坏。溶血补体基因（Hc）无效等位基因的存在可能是表达非常严重损伤所必需的，但并不充分。这些结果被解释为反映了两个独立基因的作用，这两个基因被命名为Carg1和Carg2（白色念珠菌抗性基因1和2）。
