Ashman R B, Fulurija A, Papadimitriou J M
School of Dentistry, University of Queensland, Brisbane, Qld., Australia.
Microb Pathog. 1998 Dec;25(6):349-52. doi: 10.1006/mpat.1998.0248.
The severity of systemic infection with the yeast Candida albicans has been shown to be under complex genetic control. C57/L mice carry an allele that is associated with an increase in tissue destruction when compared with C57Bl/6 mice; however, the gene affects only the severity of tissue lesions, and does not influence the magnitude of the fungal burden in either kidney or brain. Studies in [C57/LxC57Bl/6]F1 hybrid mice, and [C57/LxC57Bl/6]F1xC57/L backcross mice, demonstrated that the gene behaves as a simple Mendelian co-dominant.
白色念珠菌系统性感染的严重程度已被证明受复杂的基因控制。与C57Bl/6小鼠相比，C57/L小鼠携带的一个等位基因与组织破坏增加有关；然而，该基因仅影响组织损伤的严重程度，而不影响肾脏或大脑中真菌负荷的大小。对[C57/LxC57Bl/6]F1杂交小鼠和[C57/LxC57Bl/6]F1xC57/L回交小鼠的研究表明，该基因表现为简单的孟德尔共显性。
