Hadfield M G, Luo V Y, Williams R L, Ward J D, Russo C P
Division of Neuropathology, Medical College of Virginia/Virginia Commonwealth University, Richmond, USA.
Pediatr Neurosurg. 1996 Aug;25(2):100-4. doi: 10.1159/000121104.
A 1-year-old female infant presented with a large 7-8 cm Ewing's sarcoma of the left parietal calvarium. It deeply indented the subjacent hemisphere. Wide surgical excision was followed by chemotherapy but not radiation. The patient was clinically free of tumor when she expired 9 months later of sepsis. Though primary Ewing's sarcoma of the skull is said to be relatively rare, we have tabulated 37 cases of this disorder, including the present one (we excluded mandibular tumors (> 100 cases) since they are not usually treated by neurosurgeons). The mean age was 11 years and of those available to follow-up, three quarters were tumor-free 6 months to 7 years postsurgery. The remainder survived an average of 21 months. Ewing's tumors of the calvarium generally grant a favorable prognosis following surgery and/or radiation and chemotherapy. Those at the base of the brain may be more difficult to eradicate. In addition to primary Ewing's tumors, metastases to the skull and the brain from other primary sources in the skeleton have been documented in several reports.
一名1岁女婴，左顶骨有一个7 - 8厘米大的尤因肉瘤。它深深压迫下方的脑半球。广泛手术切除后进行了化疗，但未进行放疗。患者9个月后因败血症死亡时临床无肿瘤。虽然颅骨原发性尤因肉瘤据说相对罕见，但我们已将37例这种疾病制成表格，包括本例（我们排除了下颌肿瘤（>100例），因为它们通常不由神经外科医生治疗）。平均年龄为11岁，在可随访的患者中，四分之三在术后6个月至7年无肿瘤。其余患者平均存活21个月。颅骨尤因肿瘤通常在手术和/或放疗及化疗后预后良好。脑底部的肿瘤可能更难根除。除了原发性尤因肿瘤外，几份报告中还记录了骨骼其他原发部位转移至颅骨和脑的情况。
