Shin L M, Kosslyn S M, McNally R J, Alpert N M, Thompson W L, Rauch S L, Macklin M L, Pitman R K
Department of Psychology, Harvard University, Cambridge, Mass, USA.
Arch Gen Psychiatry. 1997 Mar;54(3):233-41. doi: 10.1001/archpsyc.1997.01830150057010.
Relative regional cerebral blood flow (rCBF) changes were measured in Vietnam combat veterans with and without posttraumatic stress disorder (PTSD) during exposure to combat-related stimuli.
Positron emission tomography was used to measure rCBF in 7 combat veterans with PTSD (PTSD group) and 7 healthy combat veterans (control group) who viewed and generated visual mental images of neutral, negative, and combat-related pictures.
Unlike control subjects, subjects with PTSD had increased rCBF in ventral anterior cingulate gyrus and right amygdala when generating mental images of combat-related pictures; when viewing combat pictures, subjects with PTSD showed decreased rCBF in Broca's area.
Results suggest that ventral anterior cingulate gyrus and right amygdala play a role in the response of combat veterans with PTSD to mental images of combat-related scenes. Reexperiencing phenomena of PTSD, which often involve emotional visual mental imagery, may be likewise associated with increased rCBF in these regions.
在接触与战斗相关的刺激时，对患有和未患有创伤后应激障碍（PTSD）的越南退伍军人的相对局部脑血流量（rCBF）变化进行了测量。
使用正电子发射断层扫描来测量7名患有PTSD的退伍军人（PTSD组）和7名健康退伍军人（对照组）的rCBF，这些人观看并生成了中性、负面和与战斗相关图片的视觉心理图像。
与对照组受试者不同，患有PTSD的受试者在生成与战斗相关图片的心理图像时，腹侧前扣带回和右杏仁核的rCBF增加；在观看战斗图片时，患有PTSD的受试者在布洛卡区的rCBF降低。
结果表明，腹侧前扣带回和右杏仁核在患有PTSD的退伍军人对与战斗相关场景的心理图像的反应中起作用。PTSD的重新体验现象通常涉及情绪化的视觉心理意象，可能同样与这些区域的rCBF增加有关。
