Cho B R
Avian Dis. 1977 Jul-Sep;21(3):394-401.
Turkey herpesvirus (HVT) viremia was studied at 3-week intervals through 21 weeks of age in individual chickens of experimental (WSU-VS) and commercial strains (C-WL) of White Leghorns vaccinated with graded doses of HVT. HVT viremia was consistently detectable in all WSU-VS birds through 21 weeks postvaccination (PV) regardless of vaccine dose employed, whereas the viremia could not be detected in some of the C-WL birds 9 to 15 weeks PV and thereafter. C-WL birds that lost detectable viremia remained so up to 21 weeks PV, or returned to low levels of viremia which was followed in some birds again by no detectable viremia. Viremia titers were significantly lower in the C-WL than in the WSU-VS birds despite the same vaccination. Both strains of chickens exhibited significantly lower viremia titers when vaccinated with 240 plaqueforming units (PFU) than with 1,480 or 6,600 PFU of HVT, and other C-WL birds lost detectable viremia earlier and more frequently with smaller vaccine doses. This observation indicated a possible genetic difference between the two strains of chickens in susceptibility and viremic response to HVT as well as dose-dependence of HVT viremia.
在接种不同剂量火鸡疱疹病毒（HVT）的实验用白来航鸡（WSU-VS品系）和商用白来航鸡（C-WL品系）个体中，每隔3周对其HVT病毒血症进行研究，直至21周龄。在接种疫苗后21周内，无论使用何种疫苗剂量，所有WSU-VS品系鸡只均能持续检测到HVT病毒血症，而在部分C-WL品系鸡只中，接种疫苗后9至15周及之后无法检测到病毒血症。失去可检测到的病毒血症的C-WL品系鸡只在接种疫苗后21周内一直保持这种状态，或者病毒血症恢复到低水平，随后在部分鸡只中再次检测不到病毒血症。尽管接种的疫苗相同，但C-WL品系鸡只的病毒血症滴度显著低于WSU-VS品系鸡只。与接种1480或6600个空斑形成单位（PFU）的HVT相比，两种品系的鸡接种240 PFU的HVT时，病毒血症滴度均显著降低，并且其他C-WL品系鸡只使用较小疫苗剂量时，更早且更频繁地失去可检测到的病毒血症。这一观察结果表明，两种品系鸡在对HVT的易感性和病毒血症反应以及HVT病毒血症的剂量依赖性方面可能存在遗传差异。
