Donahoe J P, Kleven S H
Avian Dis. 1977 Jul-Sep;21(3):436-9.
Tests were made of the effectiveness of herpesvirus of turkeys (HVT) vaccine in preventing tumorigenesis following challenge with a neoplastically transformed Marek's disease tumor cell line (MSB-1). HVT vaccine prevented tumors due to MSB-1 inoculation whereas 21.4% of unvaccinated controls had tumors. The results support, but do not prove, the theory that HVT acts through enhancement of cell-mediated immunity against MDV-transformed cells. The drawbacks of using MSB-1 cells in this experiment and the need for true Marek's transplantable tumor cells are discussed.
对火鸡疱疹病毒（HVT）疫苗在预防用肿瘤转化的马立克氏病肿瘤细胞系（MSB-1）攻击后肿瘤发生方面的有效性进行了测试。HVT疫苗可预防因接种MSB-1而导致的肿瘤，而未接种疫苗的对照组中有21.4%出现了肿瘤。这些结果支持但未证明HVT通过增强针对MDV转化细胞的细胞介导免疫起作用这一理论。讨论了在该实验中使用MSB-1细胞的缺点以及对真正的马立克氏可移植肿瘤细胞的需求。
