Sharma J M
Avian Dis. 1984 Jul-Sep;28(3):629-40.
Chickens inoculated at hatch with pathogenic infectious bursal disease virus (IBDV) and the turkey herpesvirus (HVT) vaccine were poorly protected against challenge at 1 week with virulent Marek's disease virus (MDV). However, if vaccination with HVT preceded IBDV inoculation such as by embryonal vaccination with HVT and exposure to IBDV at hatch, or by vaccination at hatch and IBDV exposure 5 days or longer postvaccination, then the vaccinal efficacy of HVT was not influenced. Further, the inhibitory effect of pathogenic IBDV was transient: chickens that received IBDV and HVT at hatch were poorly protected against challenge with virulent MDV at 1 week but not against challenge at 2 weeks of age. Pathogenic IBDV routinely interfered in vaccine efficacy of HVT in chickens lacking maternal antibody to IBDV but not in chickens that had such antibodies at the time of exposure to IBDV. In certain experiments, pathogenic IBDV caused a high rate of mortality in newly hatched chicks. Chickens receiving IBDV and MDV had a lower incidence of Marek's disease than those receiving MDV alone.
在孵化时接种致病性传染性法氏囊病病毒（IBDV）和火鸡疱疹病毒（HVT）疫苗的鸡，在1周龄时用强毒马立克氏病病毒（MDV）攻击时保护效果不佳。然而，如果先接种HVT再接种IBDV，比如通过在胚胎期接种HVT并在孵化时接触IBDV，或者在孵化时接种HVT并在接种后5天或更长时间接触IBDV，那么HVT的疫苗效力不受影响。此外，致病性IBDV的抑制作用是短暂的：在孵化时接受IBDV和HVT的鸡，在1周龄时用强毒MDV攻击时保护效果不佳，但在2周龄时攻击时则不然。致病性IBDV通常会干扰缺乏IBDV母源抗体的鸡中HVT的疫苗效力，但在接触IBDV时具有此类抗体的鸡中则不会。在某些实验中，致病性IBDV在新孵出的雏鸡中导致了高死亡率。接受IBDV和MDV的鸡马立克氏病的发病率低于仅接受MDV的鸡。
