Vaezi M F, Richter J E
Division of Gastroenterology, University of Alabama at Birmingham, USA.
South Med J. 1997 Mar;90(3):305-11. doi: 10.1097/00007611-199703000-00008.
To define the role of ambulatory pH monitoring in evaluating chronic cough, we studied esophageal pH values of patients referred to a gastroenterology laboratory. Chronic cough was evaluated in 31 patients, who were grouped based on response to treatments; 11 patients (35.5%) had gastroesophageal reflux (GER)-related cough, 11 (35.5%) had pulmonary/otorhinolaryngologic-related cough (1 bronchitis, 6 asthma, 2 postnasal drip, 1 pneumonia), and 9 patients (29%) had cough of unknown etiology. Esophageal pH values of groups were compared. Excessive acid reflux distally (upright and supine) and proximally (upright) and cough symptom frequency related to acid reflux were significantly higher in patients with GER. Esophageal pH monitoring had good sensitivity (91%), specificity (82%), and positive (83%) and negative (90%) predictive values in identifying GER-related cough. In summary, ambulatory pH monitoring is an excellent test for identifying patients with GER-related cough.
为了明确动态pH监测在评估慢性咳嗽中的作用，我们研究了转诊至胃肠病学实验室的患者的食管pH值。对31例患者进行了慢性咳嗽评估，并根据治疗反应将其分组；11例患者（35.5%）有胃食管反流（GER）相关咳嗽，11例（35.5%）有肺/耳鼻喉科相关咳嗽（1例支气管炎、6例哮喘、2例鼻后滴漏、1例肺炎），9例患者（29%）咳嗽病因不明。比较了各组的食管pH值。GER患者远端（直立位和仰卧位）和近端（直立位）的过度酸反流以及与酸反流相关的咳嗽症状频率显著更高。食管pH监测在识别GER相关咳嗽方面具有良好的敏感性（91%）、特异性（82%）以及阳性（83%）和阴性（90%）预测值。总之，动态pH监测是识别GER相关咳嗽患者的一项出色检查。
