Sutherland W H, Ball M J, Walker H
Department of Medicine, University of Otago Medical School, Dunedin, New Zealand.
Eur J Clin Nutr. 1997 Mar;51(3):172-6. doi: 10.1038/sj.ejcn.1600379.
Plasma cholesteryl ester transfer activity influences the distribution of cholesterol among plasma lipoproteins and changes in its activities may influence the response of plasma lipoprotein cholesterol levels to increased cholesterol intake in the form of eggs.
The aim of the study was to determine the effect of increased egg intake on plasma newly synthesized cholesteryl ester transfer (NCET) activity and plasma lipids and lipoprotein levels in free-living men and women.
The study was longitudinal and included a 12 d intervention arm and a similar control period immediately prior to the intervention to account for any changes in variables with time.
Thirty two healthy subjects aged 20-57 y and consuming self-selected diets were recruited. Twelve men and 14 women were entered into the intervention arm of the study. Twelve of these subjects and six others were in the control group.
Subjects who participated in the intervention phase received one additional egg per day.
Plasma NCET activity decreased significantly (P = 0.05) in the 26 subjects who consumed an extra egg, mainly due to a significant (P = 0.02) decrease (-13.4%) in the activity in the women. Plasma cholesterol and apolipoprotein B-containing lipoprotein cholesterol increased significantly (P < 0.05) in the intervention group and in men (P = 0.02) but not in women. Age was correlated significantly (r = 0.519, P < 0.01) with the change in plasma NCET activity in all subjects and in men (r = -0.644, P < 0.05). The decrease in plasma NCET activity was significantly (P = 0.02) less in the lowest tertile compared with other tertiles of self-reported habitual dietary cholesterol intake independent of age and gender.
These data suggest that an increase in dietary cholesterol reduces plasma NCET activity particularly in women and older men and individuals with higher habitual intakes of cholesterol. Furthermore, a reduction in plasma NCET activity may tend to limit the increase in apoB-containing lipoprotein cholesterol in women during increased egg consumption.
血浆胆固醇酯转移活性影响胆固醇在血浆脂蛋白之间的分布，其活性变化可能会影响血浆脂蛋白胆固醇水平对以鸡蛋形式增加的胆固醇摄入量的反应。
本研究旨在确定增加鸡蛋摄入量对自由生活的男性和女性血浆新合成胆固醇酯转移（NCET）活性以及血浆脂质和脂蛋白水平的影响。
本研究为纵向研究，包括一个为期12天的干预组以及在干预前一个类似的对照组，以考虑变量随时间的任何变化。
招募了32名年龄在20 - 57岁、食用自选饮食的健康受试者。其中12名男性和14名女性进入研究的干预组。这些受试者中的12名和另外6名在对照组。
参与干预阶段的受试者每天额外摄入一个鸡蛋。
在额外摄入一个鸡蛋的26名受试者中，血浆NCET活性显著降低（P = 0.05），主要是由于女性的活性显著降低（P = 0.02）（降低了13.4%）。干预组和男性的血浆胆固醇和含载脂蛋白B的脂蛋白胆固醇显著增加（P < 0.05），但女性未增加。在所有受试者中，年龄与血浆NCET活性变化显著相关（r = 0.519，P < 0.01），在男性中也是如此（r = -0.644，P < 0.05）。与自我报告的习惯性饮食胆固醇摄入量的其他三分位数相比，最低三分位数的血浆NCET活性降低幅度显著较小（P = 0.02），且不受年龄和性别的影响。
这些数据表明，饮食中胆固醇的增加会降低血浆NCET活性，尤其是在女性、老年男性以及习惯性胆固醇摄入量较高的个体中。此外，在增加鸡蛋摄入量期间，血浆NCET活性的降低可能会倾向于限制女性含载脂蛋白B的脂蛋白胆固醇的增加。
