Wall C R, Swanson C E, Cleghorn G J
Children's Nutrition Research Centre, Royal Children's Hospital, Herston, Queensland, Australia.
J Gastroenterol Hepatol. 1997 Jan;12(1):24-8. doi: 10.1111/j.1440-1746.1997.tb00340.x.
A prospective randomized trial was conducted to compare the efficacy of a rice-based oral rehydration solution (ORS) with glucose ORS in infants and children under 5 years of age with acute diarrhoea and mild to moderate dehydration (< 10%). One hundred children presenting to a large metropolitan teaching hospital were eligible for entry to the study and were randomized to receive rice ORS or glucose ORS. Outcome measures were stool output (SO), duration of illness (DD) and recovery time to introduction of other fluids (RTF) and diet (RTD). Significant differences were found for all outcome measures in favour of the rice ORS group. Mean SO was lower (160 vs 213 mL; P < 0.02), mean DD was reduced (17.3 vs 24.3 h; P = 0.03) and median RTF was decreased (12.7 vs 18.1 h; P < 0.001) in the rice ORS group compared with the glucose ORS group. The median time to introduction of diet and mean length of hospital stay showed similar significant reductions. Our study has shown rice ORS to be an acceptable alternative to glucose ORS in young children and have shown that it is significantly more effective in reducing the course of diarrhoeal illness and the time taken to return to normal drinking and eating habits.
开展了一项前瞻性随机试验，比较以大米为基础的口服补液盐（ORS）与葡萄糖ORS对5岁以下患有急性腹泻和轻度至中度脱水（<10%）的婴幼儿的疗效。在一家大型都市教学医院就诊的100名儿童符合纳入研究的条件，并被随机分配接受大米ORS或葡萄糖ORS。观察指标为粪便排出量（SO）、病程（DD）以及恢复到可摄入其他液体（RTF）和饮食（RTD）的时间。所有观察指标均发现有利于大米ORS组的显著差异。与葡萄糖ORS组相比，大米ORS组的平均SO更低（160 vs 213 mL；P<0.02），平均DD缩短（17.3 vs 24.3 h；P = 0.03）且中位RTF降低（12.7 vs 18.1 h；P<0.001）。引入饮食的中位时间和平均住院时间也出现了类似的显著缩短。我们的研究表明，大米ORS是幼儿替代葡萄糖ORS的可接受选择，且已表明它在缩短腹泻病程以及恢复正常饮水和饮食习惯所需时间方面显著更有效。
