Peiffer R L, Nobles R D, Carter J, Pandya A D, Osborne C, Freedman S
Department of Ophthalmology, School of Medicine, University of North Carolina, Chapel Hill 27599-7040, USA.
Ophthalmic Surg Lasers. 1997 Mar;28(3):223-30.
To experimentally compare and contrast the internal sclerostomy produced using a mechanical trephine with that made by an Nd:YAG laser, and to evaluate the healing patterns, efficacy, and technical advantages of each method.
Four healthy dogs with normal eyes were used in this study. The left eye of each dog had an internal sclerostomy performed with an automated mechanical trephine. The right eye of each dog had an internal sclerostomy performed with an Nd:YAG laser. Postoperatively, the intraocular pressure of each eye was measured at regular intervals. The dogs were euthanized successively at 1, 2, 3, and 4 weeks postoperatively, and the morphology of the surgical sites was studied.
The Nd:YAG laser was easier to manipulate and technically less demanding than the mechanical trephine. However, the Nd:YAG laser induced more prominent corneal edema and conjunctival hyperemia compared with the automated trephine. Morphology of the tissue response showed tissue necrosis and greater inflammation with the Nd:YAG laser than with the automated trephine.
These two techniques demonstrate differences in technical demands and tissue response. Both are characterized by minimal reactive fibrosis of the episcleral and Tenon's capsule fibroblast.
通过实验比较和对比使用机械环钻制作的内巩膜造口术与使用Nd:YAG激光制作的内巩膜造口术，并评估每种方法的愈合模式、疗效和技术优势。
本研究使用4只健康的正常眼犬。每只犬的左眼使用自动机械环钻进行内巩膜造口术。每只犬的右眼使用Nd:YAG激光进行内巩膜造口术。术后定期测量每只眼睛的眼压。在术后1、2、3和4周依次对犬实施安乐死，并研究手术部位的形态。
与机械环钻相比，Nd:YAG激光更易于操作，对技术的要求更低。然而，与自动环钻相比，Nd:YAG激光引起的角膜水肿和结膜充血更明显。组织反应的形态学显示，与自动环钻相比，Nd:YAG激光引起的组织坏死和炎症更严重。
这两种技术在技术要求和组织反应方面存在差异。两者的特点均为巩膜上组织和成纤维细胞的反应性纤维化程度最低。
