Rodriguez-Argüelles M C, Belicchi Ferrari M, Gasparri Fava G, Pelizzi C, Pelosi G, Albertini R, Bonati A, Dall'Aglio P P, Lunghi P, Pinelli S
Departamènto de Quimica Pura y Aplicada, Universidade de Vigo, Spain.
J Inorg Biochem. 1997 Apr;66(1):7-17. doi: 10.1016/s0162-0134(96)00146-8.
The reaction of iron, nickel, copper, and zinc chlorides or acetates with acenaphthenequinone thiosemicarbazone, Haqtsc leads to the formation of novel complexes that have been characterized by spectroscopic studies (NMR, IR) and biological properties. The crystal structures of the free ligand Haqtsc 1 and of the compound [Ni(aqtsc)2].DMF 2, have also been determined by X-ray methods from diffractometer data. In 1, the conformation of the two nonequivalent molecules is governed by intramolecular hydrogen bonds, while an intermolecular hydrogen bond is responsible for dimer-like groups formation. In 2, the coordination geometry about nickel is distorted octahedral, and the two ligand molecules are terdentate monodeprotonated. Biological studies have shown that, for the first time at least up the used doses, a free ligand is active both in the inhibition of cell proliferation and in the induced differentiation on Friend erythroleukemia cells (FLC).
铁、镍、铜和锌的氯化物或醋酸盐与苊醌硫代半卡巴腙（Haqtsc）反应，生成了新型配合物，这些配合物已通过光谱研究（核磁共振、红外）和生物学性质进行了表征。游离配体Haqtsc 1和化合物[Ni(aqtsc)2].DMF 2的晶体结构也已通过X射线方法根据衍射仪数据确定。在1中，两个不等价分子的构象受分子内氢键控制，而分子间氢键则负责形成二聚体样基团。在2中，镍周围的配位几何形状为扭曲八面体，两个配体分子为三齿单去质子化。生物学研究表明，至少在所使用的剂量范围内，游离配体首次在抑制细胞增殖和诱导弗氏红白血病细胞（FLC）分化方面具有活性。
