Casas J S, Rodríguez-Argüelles M C, Russo U, Sánchez A, Sordo J, Vázquez-López A, Pinelli S, Lunghi P, Bonati A, Albertini R
Departamento de Química Inorgánica, Facultade di Farmacia, Universidade de Santiago de Compostela, Spain.
J Inorg Biochem. 1998 Mar;69(4):283-92. doi: 10.1016/s0162-0134(98)00004-x.
The complexes [SnR2(L)] (R = Me, Et, Bu, Ph; H2L = pyridoxal thiosemicarbazone) have been prepared and characterized. In the light of the spectral properties of the complexes in the solid state (IR, mass, Mössbauer) the bideprotonated thiosemicarbazonato anion is O(phenolic)-, N(3)-, S-bonded to the tin atom which probably has trigonal bipyramidal coordination with N(3) atom and R groups occupying equatorial positions. NMR ( 1H, 13C and 119Sn) data in CDCl3 or DMSO-d6 suggest that this coordinative picture remains in these solutions. The ethyl, butyl and phenyl derivatives suppress proliferation of Friend erithroleukaemia cells (FLC). Of the pyridoxal thiosemicarbazone complexes so far evaluated. [SnBu2(L)] and [SnPh2(L)] showed the lowest thresholds for inhibition of FLC proliferation. The effects of these compounds on DMSO-induced differentiation of FLC, DNA synthesis and reverse transcriptase were also assayed.
已制备并表征了配合物[SnR2(L)]（R = 甲基、乙基、丁基、苯基；H2L = 吡哆醛硫代半卡巴腙）。根据固态配合物的光谱性质（红外光谱、质谱、穆斯堡尔谱），双质子化硫代半卡巴腙阴离子通过酚羟基氧、3位氮和硫与锡原子键合，锡原子可能具有三角双锥配位结构，3位氮原子和R基团占据赤道位置。CDCl3或DMSO-d6中的核磁共振（1H、13C和119Sn）数据表明，这种配位情况在这些溶液中仍然存在。乙基、丁基和苯基衍生物可抑制弗氏红白血病细胞（FLC）的增殖。在迄今为止评估的吡哆醛硫代半卡巴腙配合物中，[SnBu2(L)]和[SnPh2(L)]对FLC增殖抑制的阈值最低。还测定了这些化合物对DMSO诱导的FLC分化、DNA合成和逆转录酶的影响。
