Sikuler E, Shnaider A, Zilberman D, Hilzenrat N, Shemer-Avni Y, Neumann L, Buskila D
Department of Medicine B, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.
J Clin Gastroenterol. 1997 Mar;24(2):87-9. doi: 10.1097/00004836-199703000-00008.
An association between chronic hepatitis C (HCV) infection and non-Hodgkin's lymphoma has been reported. We carried out this study to evaluate the possibility of an association between HCV infection and other extrahepatic malignancies. The medical records of 103 unselected, consecutively chosen, anti HCV-positive and 105 hepatitis B surface antigen (HBsAg)-positive patients attending the liver clinic or hospitalized in the Department of Medicine were reviewed. Patients in whom anti-HCV positivity was detected after the malignancy was diagnosed were excluded. Malignancy rates in the general Israeli population were obtained from the Israeli cancer registry. The ages of anti-HCV-positive and HBsAg-positive patients were 54 +/- 16 (+/-SD) (range, 15-84) and 45 +/- 12 (range, 20-78) years, respectively; the male/female ratios were 50/53 and 73/32, respectively. Extrahepatic malignancies were found in 15 (14.6%) of the anti-HCV and in three (2.9%) of the HBsAg-positive patients. Thirteen of the malignancies were found among the 60 anti-HCV-positive patients aged > or =55 years old. Only one malignancy was found among the 28 HBsAg-positive patients of the same age group (p < 0.01). The rate of extrahepatic malignancies in these HCV-infected patients was significantly higher (p < 0.01) than expected in the general population. An association between HCV infection and extrahepatic malignancy may exist, but further prospective studies, including a large number of patients with HCV infection, will be necessary to define this observation.
已有报道称慢性丙型肝炎（HCV）感染与非霍奇金淋巴瘤之间存在关联。我们开展这项研究以评估HCV感染与其他肝外恶性肿瘤之间存在关联的可能性。我们回顾了103例未经挑选、连续入选的抗HCV阳性患者以及105例乙型肝炎表面抗原（HBsAg）阳性患者的病历，这些患者均在肝病门诊就诊或在医学科住院。在恶性肿瘤被诊断后检测出抗HCV阳性的患者被排除。以色列普通人群的恶性肿瘤发病率数据来自以色列癌症登记处。抗HCV阳性患者和HBsAg阳性患者的年龄分别为54±16（±标准差）（范围15 - 84岁）和45±12（范围20 - 78岁）；男女比例分别为50/53和73/32。在抗HCV阳性患者中有15例（14.6%）发现了肝外恶性肿瘤，在HBsAg阳性患者中有3例（2.9%）发现了肝外恶性肿瘤。在60例年龄≥55岁的抗HCV阳性患者中发现了13例恶性肿瘤。在同一年龄组的28例HBsAg阳性患者中仅发现1例恶性肿瘤（p<0.01）。这些HCV感染患者的肝外恶性肿瘤发生率显著高于（p<0.01）普通人群的预期发生率。HCV感染与肝外恶性肿瘤之间可能存在关联，但需要进一步开展前瞻性研究，包括纳入大量HCV感染患者，以明确这一观察结果。
