野生型p53诱导的细胞凋亡中CPP32和Mch3α的激活。
Activation of CPP32 and Mch3 alpha in wild-type p53-induced apoptosis.
作者信息
Chandler J M, Alnemri E S, Cohen G M, MacFarlane M
机构信息
Medical Research Council Toxicology Unit, University of Leicester, U.K.
出版信息
Biochem J. 1997 Feb 15;322 ( Pt 1)(Pt 1):19-23. doi: 10.1042/bj3220019.
Abstract
DNA-damaging agents induce apoptosis primarily by a p53-dependent pathway. LTR6 cells containing a temperature-sensitive p53 were used to dissect further the mechanisms of p53-induced apoptosis. Apoptosis was accompanied by the processing and activation of CPP32 and Mch3 alpha, together with the cleavage of poly(ADP-ribose) polymerase and lamin B1. These results demonstrate a critical role for the activation of interleukin-1 beta-converting enzyme-like proteases in p53-induced apoptosis.
摘要
DNA损伤剂主要通过p53依赖途径诱导细胞凋亡。利用含有温度敏感型p53的LTR6细胞进一步剖析p53诱导细胞凋亡的机制。细胞凋亡伴随着CPP32和Mch3α的加工与激活，以及聚（ADP-核糖）聚合酶和核纤层蛋白B1的裂解。这些结果证明白细胞介素-1β转化酶样蛋白酶的激活在p53诱导的细胞凋亡中起关键作用。
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J Biol Chem. 1996 Oct 25;271(43):27099-106. doi: 10.1074/jbc.271.43.27099.
2
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3
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