Kimura M, Tsuruta S, Yoshida T
Division of Allergy, Clinical Immunology and Infectious Diseases, Shizuoka Children's Hospital.
Arerugi. 1997 Jan;46(1):34-41.
Allergen-specific lymphocyte proliferation was measured in 24 children with atopic dermatitis and 20 non-atopic controls. The level of house dust mite-specific S.I.F. (stimulation index measured by flow cytometry) in the atopic children was significantly higher than that in the non-atopic controls in every age-group, suggesting that the elevation of the mite-specific S.I.F. level is related to the development of atopic dermatitis. The level of house dust mite-specific S.I.F. correlated significantly with the level of house dust mite-specific IgE-RAST in older children (r < 0.73, p < 0.001), indicating that S.I.F. reflects the activity of lymphocytes competent to promote the production of IgE. In the atopic infants, there was no significant positive correlation between the levels of mite-specific S.I.F. and mite-specific IgE-RAST since, although the former was usually elevated the latter was often very low or negative. The result suggests that the sensitization of T lymphocytes to house dust mite begins as early as in infancy prior to the development of mite-specific IgE antibody.
对24名特应性皮炎患儿和20名非特应性对照儿童进行了变应原特异性淋巴细胞增殖检测。在每个年龄组中，特应性儿童的屋尘螨特异性S.I.F.（通过流式细胞术测量的刺激指数）水平显著高于非特应性对照儿童，这表明螨特异性S.I.F.水平的升高与特应性皮炎的发生有关。在大龄儿童中，屋尘螨特异性S.I.F.水平与屋尘螨特异性IgE-RAST水平显著相关（r < 0.73，p < 0.001），表明S.I.F.反映了能够促进IgE产生的淋巴细胞的活性。在特应性婴儿中，螨特异性S.I.F.水平与螨特异性IgE-RAST水平之间没有显著的正相关，因为尽管前者通常升高，但后者往往非常低或为阴性。结果表明，T淋巴细胞对屋尘螨的致敏早在婴儿期就开始了，早于螨特异性IgE抗体的产生。
