Endo K, Fukuzumi T, Adachi J, Kojima M, Aoki T, Yoshida M, Morita K, Nari T, Tsujino M
Habikino Hospital of Osaka Prefecture.
Arerugi. 1997 Oct;46(10):1013-24.
By a randomized double blind control trial we studied the effect of vacuum cleaning of room floors, mattresses and quilts for twelve months on clinical symptoms and laboratory data of atopic dermatitis patients. All patients used the identical new vacuum cleaners. Thirty patients (3-12 years of age) with relatively stable skin conditions were randomly allocated to either of the following two groups. In the monitor group we visited patient's home every three weeks and mite specialists cleaned drastically the room floors, mattresses and quilts and the patient continued to clean in the same way in-between. In the control group we visited similarly but the cleaning was made insufficiently which was also followed by the patient. But, at 2 occasions (the first and the last visits), cleaning was made drastically also in the control group. Thus the mite numbers were counted precisely at the start and the end of the experiment both in the monitor and control groups. Each patient was seen every six weeks by the same doctor and estimated of his symptoms using our unique scoring system (Fig. 1). At the start and the end of the study, total IgE and specific IgE antibodies to house dust mites in the serum were evaluated. The monitor group showed a tendency to count smaller number of mites than the control group after a year, when there was a significant difference only in quilts. However, a statistically significant decrease in the mite counts was observed only in room floors and not in mattresses and quilts both in the monitor and control groups (Fig. 2). Clinical scores after a year significantly improved only in the monitor group and not in the control group (Fig. 3). Serum IgE value and specific antibody titer to house dust mites were not changed significantly after the trial in both groups. As a conclusion, vacuum cleaning of the patient's room improved the clinical symptoms of atopic dermatitis but this could not be related to the reduction of house dust mite number.
通过一项随机双盲对照试验，我们研究了对房间地板、床垫和被子进行为期十二个月的真空清洁对特应性皮炎患者临床症状和实验室数据的影响。所有患者均使用相同的新型真空吸尘器。30名皮肤状况相对稳定的患者（3至12岁）被随机分为以下两组。在监测组中，我们每三周探访患者家中一次，由螨虫专家对房间地板、床垫和被子进行深度清洁，患者在中间时间段也以同样方式进行清洁。在对照组中，我们同样每三周探访一次，但清洁力度不足，患者随后也照此进行。不过，在2个时间点（首次和末次探访），对照组也进行了深度清洁。因此，在实验开始和结束时精确统计了监测组和对照组中的螨虫数量。同一位医生每六周对每位患者进行一次检查，并使用我们独特的评分系统评估其症状（图1）。在研究开始和结束时，对血清中总IgE和针对屋尘螨的特异性IgE抗体进行了评估。一年后，监测组的螨虫数量有比对照组少的趋势，此时仅被子上的螨虫数量有显著差异。然而，在监测组和对照组中，仅在房间地板上观察到螨虫数量有统计学意义的减少，而床垫和被子上则没有（图2）。一年后的临床评分仅在监测组中显著改善，对照组则没有（图3）。试验后两组的血清IgE值和针对屋尘螨的特异性抗体滴度均未发生显著变化。结论是，对患者房间进行真空清洁改善了特应性皮炎的临床症状，但这与屋尘螨数量的减少无关。
