Ligated renal pedicles and duration of action of neostigmine and pyridostigmine.

1. The duration of neostigmine or pyridostigmine antagonism of a (+)-tubocurarine (Tc) neuromuscular blockade was determined in the cat anterior tibialis-peroneal nerve preparation with and without ligated renal pedicles. 2. The infusion rate of Tc required to maintain a 90% depression of twitch tension was reduced from 8.8 +/- 1.4 (s.e.) to 3.4 +/- 0.6 mugkg-1 min-1 by renal pedicle ligation. 3. Renal pedicle ligation resulted in an increased duration of antagonism of Tc by both neostigmine and pyridostigmine.