分泌型磷脂酶A2和C反应蛋白在清除受损细胞中的作用。

A role for secretory phospholipase A2 and C-reactive protein in the removal of injured cells.

作者信息

Hack C E, Wolbink G J, Schalkwijk C, Speijer H, Hermens W T, van den Bosch H

机构信息

Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands.

出版信息

Immunol Today. 1997 Mar;18(3):111-5. doi: 10.1016/s0167-5699(97)01002-5.

DOI:10.1016/s0167-5699(97)01002-5

PMID:9078682

Abstract

The acute phase response is initiated in response to infection or physical trauma and is characterized by an increase in the levels of some plasma proteins. Here, Erik Hack and colleagues suggest that the combined actions of two of these acute phase proteins, secretory phospholipase A2 and C-reactive protein, may serve to promote phagocytosis of injured cells and tissue debris, thereby enhancing inflammation and tissue damage.

摘要

急性期反应是机体对感染或物理创伤作出的反应，其特征是某些血浆蛋白水平升高。在此，埃里克·哈克及其同事指出，其中两种急性期蛋白，即分泌型磷脂酶A2和C反应蛋白的联合作用，可能有助于促进受损细胞和组织碎片的吞噬作用，从而加剧炎症和组织损伤。