Gause W C, Halvorson M J, Lu P, Greenwald R, Linsley P, Urban J F, Finkelman F D
Dept of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Immunol Today. 1997 Mar;18(3):115-20. doi: 10.1016/s0167-5699(97)01005-0.
The development of IL-4-producing effector T cells during a type 2 immune response requires signaling through B7 ligands, but probably not CD40 ligands. Here, William Gause and colleagues review the still controversial role of CD28 and CTLA-4 on T cells, and B7-1 and B7-2 on antigen-presenting cells, and provide a model to incorporate recent findings.
在2型免疫反应过程中，产生白细胞介素-4的效应T细胞的发育需要通过B7配体进行信号传导，但可能不需要CD40配体。在此，威廉·高斯及其同事回顾了CD28和CTLA-4在T细胞上以及B7-1和B7-2在抗原呈递细胞上仍存在争议的作用，并提供了一个纳入近期研究结果的模型。
