Harris D L, Alexander T J, Whipp S C, Robinson I M, Glock R D, Matthews P J
J Am Vet Med Assoc. 1978 Feb 15;172(4):468-71.
Transmission experiments were carried out in gnotobiotic pigs to determine whether lesions typical of swine dysentery could be produced by oral inoculation of Treponema hyodysenteriae in combination with Bacteroides vulgatus or Fusobacterium necrophorum, or both. Each of the organisms had been isolated from swine with early lesions of the disease. Lesions were not found in 6 pigs inoculated with T hyodysenteriae alone, in 4 pigs given F necrophorum and T hyodysenteriae, or in 4 pigs given B vulgatus and F necrophorum. Lesions typical of swine dysentery developed in 8 pigs given B vulgatus, F necrophorum, and T hyodysenteriae as well as in 3 of 4 pigs given B vulgatus and T hyodysenteriae. In both of these groups, the inoculated bacteria were recovered from the colon, and T hyodysenteriae was demonstrated in the colonic crypts, epithelium, and lamina propria. The pathogenicity of the T hyodysenteriae was shown by the development of characteristic signs and lesions of swine dysentery in 12 of 14 naturally farrowed pigs inoculated with T hyodysenteriae alone.
在无菌猪身上进行了传播实验，以确定通过口服接种猪痢疾密螺旋体与脆弱拟杆菌或坏死梭杆菌或两者结合，是否能产生猪痢疾的典型病变。每种微生物均从患有该病早期病变的猪身上分离得到。单独接种猪痢疾密螺旋体的6头猪、接种坏死梭杆菌和猪痢疾密螺旋体的4头猪以及接种脆弱拟杆菌和坏死梭杆菌的4头猪均未发现病变。接种脆弱拟杆菌、坏死梭杆菌和猪痢疾密螺旋体的8头猪以及接种脆弱拟杆菌和猪痢疾密螺旋体的4头猪中的3头出现了猪痢疾的典型病变。在这两组中，均可从结肠中分离出接种的细菌，并且在结肠隐窝、上皮和固有层中发现了猪痢疾密螺旋体。单独接种猪痢疾密螺旋体的14头自然分娩猪中有12头出现了猪痢疾的特征性体征和病变，显示了猪痢疾密螺旋体的致病性。
