Rauch D, Drescher P, Knes J M, Madsen P O
Department of Surgery, University of Wisconsin, School of Medicine and VA Medical Center, Madison 53705, USA.
Urol Res. 1997;25 Suppl 1:S21-3. doi: 10.1007/BF00942043.
Vasoconstriction caused by iodinated contrast media (CM) has been considered specific for the renal artery only. We examined the vascular effect of CM in rabbit carotid, aorta, renal, iliac, mesenteric and celiac arteries and found that other arteries also respond with a contraction to CM. Isolated arterial rings were exposed to diatrizoate (high osmolar CM), iohexol (low osmolar CM) or glucose solution, and the isometric contraction response was expressed as percentage of an initial KCl control contraction. Diatrizoate evoked contractions of 82% (carotid), 63% (aorta), 30% (renal), 24% (iliac), 28% (mesenteric) and 18% (celiac), respectively. Iohexol caused contractions of 31% (carotid), 24% (aorta), 15% (renal) and 14% (iliac), whereas the mesenteric and celiac arteries were relaxed by iohexol. A high osmolar glucose solution elicited contractions of 78%, 77%, 11%, 27%, 3% and 5%, respectively, in the arteries. CM have contraction potency in arterial vasculature other than the renal artery.
碘化造影剂（CM）引起的血管收缩一直被认为仅对肾动脉具有特异性。我们研究了CM对兔颈动脉、主动脉、肾动脉、髂动脉、肠系膜动脉和腹腔动脉的血管效应，发现其他动脉对CM也有收缩反应。将离体动脉环暴露于泛影酸盐（高渗CM）、碘海醇（低渗CM）或葡萄糖溶液中，等长收缩反应以初始氯化钾对照收缩的百分比表示。泛影酸盐分别引起颈动脉82%、主动脉63%、肾动脉30%、髂动脉24%、肠系膜动脉28%和腹腔动脉18%的收缩。碘海醇引起颈动脉31%、主动脉24%、肾动脉15%和髂动脉14%的收缩，而肠系膜动脉和腹腔动脉则被碘海醇舒张。高渗葡萄糖溶液分别在这些动脉中引起78%、77%、11%、27%、3%和5%的收缩。CM在肾动脉以外的动脉血管系统中具有收缩效力。
