Rauch D, Drescher P, Pereira F J, Knes J M, Will J A, Madsen P O
Department of Surgery, University of Wisconsin School of Medicine, Madison, USA.
Invest Radiol. 1997 Jun;32(6):315-9. doi: 10.1097/00004424-199706000-00001.
Contrast media (CM)-induced renal vasoconstriction is an important factor in the pathogenesis of CM-induced nephrotoxicity. The effects of ionic, high-osmolar CM sodium/meglumine diatrizoate and nonionic, low-osmolar CM iohexol and iopamidol were studied in rabbit, dog, and pig renal arteries and compared with human tissue in an organ bath.
Isometric contractions were induced by increasing concentrations of CM and high-osmolar glucose solution.
Contrast media and glucose elicited contractions in human renal arteries of 32% (diatrizoate), 20% (iohexol), 30% (iopamidol), and 22% (glucose). Rabbit and dog renal arteries demonstrated contractions of 30% and 46% (diatrizoate), 15% and 23% (iohexol), 15% and 26% (iopamidol), and 11% and 40% (glucose), respectively, of the control. There was a vasorelaxing effect of all CM tested on pig renal artery.
Responses in rabbit and dog renal arteries were similar to those in human renal arteries and could serve as models for investigating CM-induced renal vasoconstriction.
造影剂（CM）诱导的肾血管收缩是CM诱导肾毒性发病机制中的一个重要因素。研究了离子型高渗CM泛影葡胺钠/葡甲胺以及非离子型低渗CM碘海醇和碘帕醇对兔、犬和猪肾动脉的影响，并在器官浴中与人体组织进行比较。
通过增加CM和高渗葡萄糖溶液的浓度诱导等长收缩。
造影剂和葡萄糖引起人体肾动脉收缩的比例分别为32%（泛影葡胺）、20%（碘海醇）、30%（碘帕醇）和22%（葡萄糖）。兔和犬肾动脉收缩分别为对照的30%和46%（泛影葡胺）、15%和23%（碘海醇）、15%和26%（碘帕醇）以及11%和40%（葡萄糖）。所有测试的造影剂对猪肾动脉均有血管舒张作用。
兔和犬肾动脉的反应与人体肾动脉相似，可作为研究造影剂诱导肾血管收缩的模型。
