大鼠慢性胆碱缺乏饮食的行为和神经化学效应
Behavioral and neurochemical effects of a chronic choline-deficient diet in the rat.
作者信息
Molinengo L, Orsetti M, Ghi P
机构信息
Istituto di Farmacologia e Farmacognosia, Universitá di Torino, Italy.
出版信息
Behav Brain Res. 1997 Mar;84(1-2):145-50. doi: 10.1016/s0166-4328(96)00143-x.
Chronic administration of a choline-deficient diet for 20 days caused no modification in ACh levels in the cortex, hippocampus and olfactory system of the rat and an increase in the density (Bmax) of the muscarinic receptors in the hippocampus. The choline-deficient diet caused no modification in noradrenaline levels and a reduction in the density of alpha1-adrenoceptors in the cortex, hippocampus and olfactory system. This paper discusses the possibility that these neurochemical effects are correlated with the reduction in spontaneous memory decay which was observed in the staircase maze after 20 days of a choline-deficient diet.
连续20天给予大鼠胆碱缺乏饮食，对其大脑皮质、海马体和嗅觉系统中的乙酰胆碱水平没有影响，但海马体中毒蕈碱受体的密度（Bmax）增加。胆碱缺乏饮食对去甲肾上腺素水平没有影响，却导致大脑皮质、海马体和嗅觉系统中α1 - 肾上腺素能受体的密度降低。本文探讨了这些神经化学效应与胆碱缺乏饮食20天后在阶梯迷宫中观察到的自发记忆衰退减少之间存在关联的可能性。
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