Antoniou K, Papadopoulou-Daifotis Z, Kafetzopoulos E
Department of Pharmacology, Medical School, University of Ioannina, Greece.
Behav Brain Res. 1998 Dec;97(1-2):13-28. doi: 10.1016/s0166-4328(98)00014-x.
It is well known that the corpus striatum is related to the sterotyped activation induced by several psychostimulants. In this study we analyzed the effects of 6-OHDA, in comparison with those of ibotenic acid lesions, into the dorsal striatum, on the behavioural pattern induced by saline or D-amphetamine treatment. A computerized technique for recording the animal motor activity was developed in order to define in a detailed way the behavioural profile in lesioned and sham-operated rats induced by the saline or D-amphetamine treatment. A 6-OHDA lesion into the dorsal striatum modified the basal behavioural pattern which was mainly characterized by reduced motor activation while ibotenic acid lesion affected the structure of the basal behavioral pattern. D-Amphetamine administration in 6-OHDA lesioned rats induced a behavioural stimulation, but a decreased motor and stereotyped activation was observed compared to the sham-operated animals treated with D-amphetamine. In contrast, D-amphetamine administration in the ibotenic acid-lesioned rats induced a motor and stereotyped activity which was not reduced compared to that seen after D-amphetamine treatment in sham-operated rats. These results suggest that these two types of lesion induced differential effects on the behavioural pattern either after saline or after D-amphetamine administration. Dopaminergic neurotransmission in the dorsal striatum plays a permissive role on the emergence of the behavioural responses, while the dorsal striatum circuitry plays a crucial role on the organization of the behavioural pattern. In addition, dopaminergic activity in this structure serves a primary control in the D-amphetamine-elicited motor activation or stereotypy, while the striatal structure is involved in the shaping of the D-amphetamine behavioural pattern.
众所周知，纹状体与多种精神兴奋剂诱导的刻板激活有关。在本研究中，我们分析了与鹅膏蕈氨酸损伤相比，向背侧纹状体注射6-羟基多巴胺（6-OHDA）对生理盐水或D-苯丙胺治疗诱导的行为模式的影响。开发了一种记录动物运动活动的计算机技术，以便详细定义生理盐水或D-苯丙胺治疗诱导的损伤大鼠和假手术大鼠的行为特征。向背侧纹状体注射6-OHDA改变了基础行为模式，其主要特征是运动激活减少，而鹅膏蕈氨酸损伤影响了基础行为模式的结构。在6-OHDA损伤的大鼠中给予D-苯丙胺会诱导行为兴奋，但与用D-苯丙胺治疗的假手术动物相比，观察到运动和刻板激活减少。相反，在鹅膏蕈氨酸损伤的大鼠中给予D-苯丙胺会诱导运动和刻板活动，与假手术大鼠中D-苯丙胺治疗后观察到的情况相比，该活动并未减少。这些结果表明，这两种类型的损伤在给予生理盐水或D-苯丙胺后对行为模式产生了不同的影响。背侧纹状体中的多巴胺能神经传递对行为反应的出现起允许作用，而背侧纹状体回路对行为模式的组织起关键作用。此外，该结构中的多巴胺能活动在D-苯丙胺引起的运动激活或刻板行为中起主要控制作用，而纹状体结构参与D-苯丙胺行为模式的形成。
