癌症化疗药物致癌风险的生物测定程序。
Bioassay program for carcinogenic hazards of cancer chemotherapeutic agents.
作者信息
Weisburger E K
出版信息
Cancer. 1977 Oct;40(4 Suppl):1935-49. doi: 10.1002/1097-0142(197710)40:4+<1935::aid-cncr2820400827>3.0.co;2-r.
Abstract
Various compounds and combinations thereof, of promise in the treatment of neoplastic diseases, were tested for possible carcinogenicity in Swiss mice and Sprague-Dawley rats. Some of the compounds were fairly active carcinogens, while others showed little or no evidence of carcinogenicity. The carcinogenicity of the drug combinations was generally less than that of the individual components.
摘要
对各种有望用于治疗肿瘤疾病的化合物及其组合，在瑞士小鼠和斯普拉格-道利大鼠中进行了潜在致癌性测试。其中一些化合物是相当活跃的致癌物，而其他一些则几乎没有或没有显示出致癌性的证据。药物组合的致癌性通常低于单个成分。
Zotero 插件