Seto Y, Nagawa H, Mori M, Tsuruo T, Muto T
First Department of Surgery, University of Tokyo Hospital; and Institute of Molecular and Cellular Bioscience, University of Tokyo, Japan.
Dig Dis Sci. 1999 Jan;44(1):75-8. doi: 10.1023/a:1026650000008.
This study was undertaken to determine the effect of 5-fluorouracil on gastrointestinal carcinogenesis. Sixty rats were divided into three groups of 20 rats each. All rats were exposed to N-methyl-N'-nitro-N-nitrosoguanidine for the first 20 weeks. Group 1 rats received intraperitoneal injections of 5-fluorouracil for the first 20 weeks and were then observed for the second 20 weeks. Group 2 rats also received 5-fluorouracil injections, but for the second 20 weeks. Group 3 rats received no 5-fluorouracil treatment. Four of 20 rats in group 1 developed an invasive adenocarcinoma. In group 3, invasive squamous cell carcinoma and adenocarcinoma developed in one rat each. None of the group 2 rats had malignant lesions. These results suggested that 5-fluorouracil is not effective in suppressing the initial stage of gastrointestinal carcinogenesis with a coexisting carcinogen. Rather, the therapeutic effect is exerted in later stages of tumor progression.
本研究旨在确定5-氟尿嘧啶对胃肠道致癌作用的影响。60只大鼠被分为三组，每组20只。所有大鼠在最初20周均暴露于N-甲基-N'-硝基-N-亚硝基胍。第1组大鼠在最初20周接受腹腔注射5-氟尿嘧啶，然后在接下来的20周进行观察。第2组大鼠也接受5-氟尿嘧啶注射，但在接下来的20周。第3组大鼠未接受5-氟尿嘧啶治疗。第1组20只大鼠中有4只发生浸润性腺癌。第3组中，各有1只大鼠发生浸润性鳞状细胞癌和腺癌。第2组大鼠均无恶性病变。这些结果表明，5-氟尿嘧啶在抑制与共存致癌物相关的胃肠道致癌作用初始阶段无效。相反，其治疗作用在肿瘤进展的后期发挥。
