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肥胖男性接受两年治疗后的体重变化、退出模式及肥胖相关危险因素的改变

Weight development, drop-out pattern and changes in obesity-related risk factors after two years treatment of obese men.

作者信息

Andersson I, Rössner S

机构信息

Obesity Unit, Karolinska Hospital, Stockholm, Sweden.

出版信息

Int J Obes Relat Metab Disord. 1997 Mar;21(3):211-6. doi: 10.1038/sj.ijo.0800389.

DOI:10.1038/sj.ijo.0800389
PMID:9080260
Abstract

OBJECTIVE

To describe a combined behavioural treatment program for obese men, the 'Gustaf' study, and to evaluate treatment success by the means of weight loss, drop-out analysis and changes in metabolic risk factors.

SUBJECTS

Eighty-six men, aged 43 +/- 9 y (mean +/- s.d.) and BMI 37.7 +/- 4.4 kg/m2, from the waiting list of the outpatient clinic and men directly approaching the Obesity Unit.

DESIGN

Combined, behavioural modification treatment, by the means of group sessions, for one hour every week over a two year period.

MAIN OUTCOME MEASURES

Weight loss and changes in risk factors after completion of one and two years study and description of treatment success in the form of changes in metabolic risk factors.

RESULTS

The one year drop-out rate was 22% and the cumulative rate after two years was 34%. Mean weight decreased significantly from start (121 kg) to one year (114 kg, P < 0.001) and to two years (115 kg, P < 0.001) in completers. Several metabolic risk factors (waist and hip circumferences, systolic blood pressure, serum cholesterol and plasma insulin) remained significantly decreased after two years of treatment. The complete metabolic syndrome was diagnosed in five men at onset, but in no one after two years. There was no difference in change of metabolic risk factors after one year between the men who lost 8-12% of initial body weight and those who lost more.

CONCLUSION

Sixty-six% (57/86) of the obese men who started in the 'Gustaf' program were still in the program after two years. In spite of the relatively modest weight loss, the men maintained a large proportion of this weight loss and also maintained their improved metabolic risk factor pattern.

摘要

目的

描述一项针对肥胖男性的综合行为治疗方案——“古斯塔夫”研究,并通过体重减轻、退出分析和代谢危险因素的变化来评估治疗效果。

对象

86名男性,年龄43±9岁(均值±标准差),体重指数(BMI)为37.7±4.4kg/m²,来自门诊候诊名单以及直接联系肥胖科的男性。

设计

通过小组会议进行为期两年的综合行为改变治疗,每周一次,每次一小时。

主要观察指标

完成一年和两年研究后的体重减轻情况以及危险因素的变化,并以代谢危险因素的变化形式描述治疗效果。

结果

一年的退出率为22%,两年后的累积退出率为34%。完成治疗者的平均体重从开始时的121kg显著下降至一年后的114kg(P<0.001)和两年后的115kg(P<0.001)。经过两年治疗后,多个代谢危险因素(腰围、臀围、收缩压、血清胆固醇和血浆胰岛素)仍显著降低。开始时有5名男性被诊断为完全代谢综合征,但两年后无一人被诊断为此病。初始体重减轻8 - 12%的男性与体重减轻更多的男性在一年后代谢危险因素的变化上没有差异。

结论

在“古斯塔夫”项目开始的肥胖男性中,两年后仍有66%(57/86)留在该项目中。尽管体重减轻相对适度,但这些男性保持了大部分的体重减轻,并且维持了改善后的代谢危险因素模式。

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