Department of Public Health and Caring Sciences/Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
Food Nutr Res. 2008;52. doi: 10.3402/fnr.v52i0.1656. Epub 2008 Mar 17.
In recent randomised prospective studies, lifestyle intervention induced a weight loss of approximately 5%.
To describe and evaluate a 2-year on-going group intervention program in clinical practice in terms of weight loss and changes in metabolic risk factors, i.e. sagital abdominal diameter (SAD), triglycerides, fasting blood glucose and blood pressure.
The aim of the intervention program was to motivate lifestyle changes concerning food intake and physical activity. The emphasis was on lifestyle modification, followed up at regular visits during 2 years. Subjects evaluated were 100 women with mean BMI 37.6 kg/m(2) and 26 men with mean BMI 36.5 kg/m(2).
One hundred of 151 enrolled women and 26 of 36 men completed the program. Mean weight decreased by 3.8 kg in women (from 103.5 to 99.7, p<0.001) and 4.4 kg in men (from 116.5 to 112.1, p<0.05), respectively. SAD decreased by 5% (p=0.001 in women, p=0.01 in men), and triglycerides by 16% in women (p=0.01) and 24% in men (p=0.001), however systolic and diastolic blood pressure increased slightly but significantly.
It is possible to perform a clinical lifestyle intervention program for outpatients on an ongoing basis with weight loss, lowered SAD and triglycerides, and a similar or lower dropout rate compared to clinical trials.
在最近的随机前瞻性研究中，生活方式干预可诱导约 5%的体重减轻。
描述和评估 2 年持续进行的临床实践中的小组干预计划，就体重减轻和代谢风险因素的变化而言，即矢状腹部直径（SAD）、甘油三酯、空腹血糖和血压。
干预计划的目的是激励关于饮食和身体活动的生活方式改变。重点是生活方式的改变，并在 2 年内定期随访。评估的受试者为 100 名平均 BMI 为 37.6kg/m²的女性和 26 名平均 BMI 为 36.5kg/m²的男性。
151 名入组女性中有 100 名（66.3%）和 36 名男性中有 26 名（72.2%）完成了该计划。女性体重平均减轻 3.8kg（从 103.5 降至 99.7，p<0.001），男性体重平均减轻 4.4kg（从 116.5 降至 112.1，p<0.05）。SAD 减少了 5%（女性 p=0.001，男性 p=0.01），女性甘油三酯降低了 16%（p=0.01），男性降低了 24%（p=0.001），但收缩压和舒张压略有但显著升高。
可以在门诊病人的基础上持续进行临床生活方式干预计划，体重减轻，SAD 和甘油三酯降低，并且与临床试验相比，辍学率相似或更低。
