通过饮食中的抗氧化剂延长小鼠的生存期取决于开始喂食这种饮食时它们的年龄。

The prolongation of survival in mice by dietary antioxidants depends on their age by the start of feeding this diet.

作者信息

Bezlepkin V G, Sirota N P, Gaziev A I

机构信息

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.

出版信息

Mech Ageing Dev. 1996 Dec 20;92(2-3):227-34. doi: 10.1016/s0047-6374(96)01840-4.

DOI:10.1016/s0047-6374(96)01840-4

PMID:9080401

Abstract

The effect of daily dietary supplements of an antioxidant mixture (AM) consisting of beta carotene, alpha tocopherol, ascorbic acid, rutin, selenium, and zinc on the survival of male C57BL/6 mice starting at 2, 9, 16, and 23 months of age was investigated. The survival of mice given AM starting at 2 and 9 months of age was found to increase significantly (from 86 to 108 days) compared to the control. The times, of 50, 90, and 100% mortality in mice given AM starting at 2 and 9 months of age increased by 16-9.5% compared to the control, whereas in mice given AM, starting at 16 and 23 months of age, no effect was observed.

摘要

研究了从2、9、16和23月龄开始每日膳食补充由β-胡萝卜素、α-生育酚、抗坏血酸、芦丁、硒和锌组成的抗氧化剂混合物（AM）对雄性C57BL/6小鼠存活的影响。发现从2和9月龄开始给予AM的小鼠的存活率与对照组相比显著提高（从86天提高到108天）。从2和9月龄开始给予AM的小鼠中50%、90%和100%死亡率的时间比对照组增加了16 - 9.5%，而从16和23月龄开始给予AM的小鼠未观察到效果。