Lipman R D, Bronson R T, Wu D, Smith D E, Prior R, Cao G, Han S N, Martin K R, Meydani S N, Meydani M
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
Mech Ageing Dev. 1998 Jul 15;103(3):269-84. doi: 10.1016/s0047-6374(98)00048-7.
The ability of augmented antioxidant consumption to alter disease incidence, lesion burden and/or longevity was studied in adult male C57BL/6 mice. Mice were fed modified AIN76 diet or modified AIN76 supplemented with vitamin E, glutathione (GSH), vitamin E and GSH, melatonin or strawberry extract starting at 18 months of age. All the mice in this study were heavier than reference populations of male C57BL/6 mice fed NIH-07 or NIH-31, which were maintained without a mid-life change in diet. Fatty liver, focal kidney atrophy and proteinacious casts in the renal tubules were observed more frequently in this study population than in the reference populations. Lesion burden and incidence of specific lesions observed amongst the various groups in this study did not differ. There were no differences observed for longevity of any of the study groups. The longevity observed in this study was similar to that previously reported for male C57BL/6 mice. Thus, diet supplementation with antioxidants initiated during middle age did not appear to affect age-associated lesions patterns, lesion burden or longevity for ad libitum fed male C57BL/6 mice.
在成年雄性C57BL/6小鼠中研究了增加抗氧化剂摄入量改变疾病发病率、损伤负担和/或寿命的能力。从18个月大开始，给小鼠喂食改良的AIN76饮食或添加了维生素E、谷胱甘肽（GSH）、维生素E和GSH、褪黑素或草莓提取物的改良AIN76饮食。本研究中的所有小鼠都比喂食NIH-07或NIH-31且饮食在中年无变化的雄性C57BL/6小鼠参考群体更重。与参考群体相比，本研究群体中更频繁地观察到脂肪肝、局灶性肾萎缩和肾小管中的蛋白质管型。本研究中各组观察到的损伤负担和特定损伤的发病率没有差异。任何研究组的寿命均未观察到差异。本研究中观察到的寿命与先前报道的雄性C57BL/6小鼠的寿命相似。因此，中年开始补充抗氧化剂的饮食似乎不会影响随意进食的雄性C57BL/6小鼠与年龄相关的损伤模式、损伤负担或寿命。
