Hölscher C, Anwyl R, Rowan M
Department of Pharmacology, Trinity College, Dublin, Republic of Ireland.
Neuroreport. 1997 Jan 20;8(2):451-4. doi: 10.1097/00001756-199701200-00015.
We have previously shown that block of high-frequency stimulation (HFS) induced long-term potentiation (LTP) of synaptic transmission in area CA1 by (1S,3S)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3S-ACPD; 5 microliters of a 20 mM solution), an agonist at group II metabotropic glutamate receptors, did not prevent animals from learning a spatial task. Here we show that the same dose of 1S,3S-ACPD also blocked the induction of HFS-induced LTP of the slope of the excitatory postsynaptic potential and of the amplitude of the population spike in the dentate gyrus. We conclude that HFS-induced LTP in the dentate gyrus is not a good model for memory formation.
我们之前已经表明，通过II组代谢型谷氨酸受体激动剂（1S,3S）-1-氨基环戊烷-1,3-二羧酸（1S,3S-ACPD；5微升20毫摩尔溶液）阻断高频刺激（HFS）诱导的海马CA1区突触传递长时程增强（LTP），并不会妨碍动物学习空间任务。在此我们表明，相同剂量的1S,3S-ACPD也阻断了HFS诱导的齿状回兴奋性突触后电位斜率和群体峰电位幅度的LTP诱导。我们得出结论，HFS诱导的齿状回LTP不是记忆形成的良好模型。
