Manoach D S, Schlaug G, Siewert B, Darby D G, Bly B M, Benfield A, Edelman R R, Warach S
Behavioral Neurology Unit, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215, USA.
Neuroreport. 1997 Jan 20;8(2):545-9. doi: 10.1097/00001756-199701200-00033.
We investigated whether a nonspatial working memory (WM) task would activate dorsolateral prefrontal cortex (DLPFC) and whether activation would be correlated with WM load. Using functional magnetic resonance imaging we measured regional brain signal changes in 12 normal subjects performing a continuous performance, choice reaction time task that requires WM. A high WM load condition was compared with a non-WM choice reaction time control condition (WM effect) and a low WM load condition (load effect). Significant changes in signal intensity occurred in the DLPFC, frontal motor regions and the intraparietal sulcus (IPS) in both comparisons. These findings support the role of DLPFC and IPS in WM and suggest that signal changes in DLPFC correlate with WM load.
我们研究了一项非空间工作记忆（WM）任务是否会激活背外侧前额叶皮层（DLPFC），以及激活是否与WM负荷相关。我们使用功能磁共振成像测量了12名正常受试者在执行一项需要WM的连续操作选择反应时任务时的局部脑信号变化。将高WM负荷条件与非WM选择反应时对照条件（WM效应）和低WM负荷条件（负荷效应）进行了比较。在这两种比较中，DLPFC、额叶运动区和顶内沟（IPS）的信号强度均发生了显著变化。这些发现支持了DLPFC和IPS在WM中的作用，并表明DLPFC中的信号变化与WM负荷相关。
