Link J M, Krohn K A, Clark J C
Imaging Research Laboratory, UW Medical Center University of Washington, Seattle 98195-6004, USA.
Nucl Med Biol. 1997 Jan;24(1):93-7. doi: 10.1016/s0969-8051(96)00181-3.
We report a single pass gas phase route to [11C]CH3I based on production of I from I2 at elevated temperature. I abstracts H from CH4 to yield CH3, which reacts with I2 to form CH3I. A fiber optic spectrometer was used to measure the I2 vapor concentration. [11C]CH3I yield increased with I2 concentration until excessive amounts of condensed I2 began to trap the 11C. The yield of [11C]CH3I was > 50% from [11C]CH4I; its specific activity was 12,000 Ci/mmole. The synthesis takes only 4 min after 11CH4 production and can be repeated without system cleanup.
我们报道了一种基于在高温下由I₂生成I的单程气相路线来制备[¹¹C]CH₃I。I从CH₄中夺取H生成CH₃，CH₃与I₂反应形成CH₃I。使用光纤光谱仪测量I₂蒸汽浓度。[¹¹C]CH₃I的产率随着I₂浓度的增加而提高，直到过量的冷凝I₂开始捕获¹¹C。由[¹¹C]CH₄I生成的[¹¹C]CH₃I的产率大于50%；其比活度为12,000 Ci/mmol。在生成¹¹CH₄后，合成仅需4分钟，并且无需系统清理即可重复进行。
