Taddei Carlotta, Gee Antony D
School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
J Labelled Comp Radiopharm. 2018 Mar;61(3):237-251. doi: 10.1002/jlcr.3596. Epub 2018 Feb 5.
[ C]Carbon dioxide ([ C]CO ) and [ C]carbon monoxide ([ C]CO) are 2 attractive precursors for labelling the carbonyl position (C═O) in a vast range of functionalised molecules (eg, ureas, amides, and carboxylic acids). The development of radiosynthetic methods to produce functionalised C-labelled compounds is required to enhance the radiotracers available for positron emission tomography, molecular, and medical imaging applications. Following a brief summary of secondary C-precursor production and uses, the review focuses on recent progress with direct C-carboxylation routes with [ C]CO and C-carbonylation with [ C]CO. Novel approaches to generate [ C]CO using CO-releasing molecules (CO-RMs), such as silacarboxylic acids and disilanes, applied to radiochemistry are described and compared with standard [ C]CO production methods. These innovative [ C]CO synthesis strategies represent efficient and reliable [ C]CO production processes, enabling the widespread use of [ C]CO chemistry within the wider radiochemistry community.
[碳-11]二氧化碳([¹¹C]CO₂)和[碳-11]一氧化碳([¹¹C]CO)是用于标记众多功能化分子（如脲、酰胺和羧酸）中羰基位置（C═O）的两种引人注目的前体。需要开发放射性合成方法来制备功能化的¹¹C标记化合物，以增加可用于正电子发射断层扫描、分子成像和医学成像应用的放射性示踪剂。在简要总结¹¹C前体的生产和用途之后，本综述重点关注使用[¹¹C]CO₂的直接¹¹C羧化路线以及使用[¹¹C]CO的¹¹C羰基化的最新进展。描述了使用一氧化碳释放分子（CO-RMs）（如硅羧酸和乙硅烷）生成[¹¹C]CO并应用于放射化学的新方法，并与标准的[¹¹C]CO生产方法进行了比较。这些创新的[¹¹C]CO合成策略代表了高效且可靠的[¹¹C]CO生产过程，能够使[¹¹C]CO化学在更广泛的放射化学领域中得到广泛应用。
