Wooldridge K G, Ketley J M
Dept of Genetics, University of Leicester, UK.
Trends Microbiol. 1997 Mar;5(3):96-102. doi: 10.1016/S0966-842X(97)01004-4.
The enteric pathogens Campylobacter jejuni and Campylobacter coli are a major cause of infectious diarrhoea. Their ability to adhere to human epithelial cells is ubiquitous and their propensity to invade cells is also well documented and requires motility and de novo protein synthesis, as well as several host factors. The molecular basis of the interaction between campylobacters and host cells is only beginning to be elucidate. The characteristics of this interaction promise to be interesting and may provide new insights into host-pathogen interactions in other enteric diseases.
肠道病原体空肠弯曲菌和结肠弯曲菌是感染性腹泻的主要病因。它们黏附于人类上皮细胞的能力普遍存在,而且其侵袭细胞的倾向也有充分记录,这需要运动性和从头蛋白质合成,以及几种宿主因子。弯曲菌与宿主细胞之间相互作用的分子基础才刚刚开始被阐明。这种相互作用的特点有望很有趣,并可能为其他肠道疾病中的宿主-病原体相互作用提供新的见解。