Singh N, Singh M P, Sharma V P
Malaria Research Centre, Field Station, Jabalpur, India.
Am J Trop Med Hyg. 1997 Feb;56(2):188-91. doi: 10.4269/ajtmh.1997.56.188.
A study was carried out in a highly malarious forested belt of central India (Madhya Pradesh) to evaluate the usefulness of a dipstick antigen-capture assay (ParaSight F) as a diagnostic method for Plasmodium falciparum appropriate for field use. In all, 1,231 patients with fever were screened in parallel with the taking of thick blood smears. The sensitivity and specificity of the dipstick test for detection of P. falciparum were 93% and 92.5%, respectively. Results also indicate that the dipstick test result became negative within seven days after initiation of curative chemotherapy in the majority of cases (95%). Tribal populations in remote forested areas are important reservoirs of P. falciparum that are mostly resistant to standard antimalarial drugs and a source of malaria to the rest of the country. Control of malaria is limited by inaccessibility, lack of medical services, public ignorance of the disease, and other technical problems. In this population, the dipstick assay was found to be highly accurate, simple, and rapid, suggesting that it may be used in remote forested areas without the need for microscopic examination. The simplicity of the dipstick test enabled administration of more effective and expensive antimalarials preventing further buildup and dissemination of resistant parasites and a return of symptoms.
在印度中部（中央邦）疟疾高发的森林地带开展了一项研究，以评估快速检测条抗原捕获检测法（ParaSight F）作为适用于现场使用的恶性疟原虫诊断方法的实用性。总共对1231名发热患者进行了筛查，并同时制作厚血涂片。快速检测条检测恶性疟原虫的敏感性和特异性分别为93%和92.5%。结果还表明，在大多数病例（95%）中，快速检测条检测结果在开始进行根治性化疗后的7天内变为阴性。偏远森林地区的部落人群是恶性疟原虫的重要储存宿主，这些人群大多对标准抗疟药物耐药，也是该国其他地区疟疾的传染源。疟疾控制受到交通不便、缺乏医疗服务、公众对该疾病的无知以及其他技术问题的限制。在这一人群中，发现快速检测条检测法高度准确、简单且快速，这表明它可用于偏远森林地区，无需显微镜检查。快速检测条检测法的简单性使得能够使用更有效且昂贵的抗疟药物，从而防止耐药寄生虫的进一步积累和传播以及症状的复发。
