Suzuki S, Ichikawa K, Nagai M, Mikoshiba M, Mori J, Kaneko A, Sekine R, Asanuma N, Hara M, Nishii Y, Yamauchi K, Aizawa T, Hashizume K
Department of Geriatrics, Shinshu University School of Medicine, Matsumoto, Japan.
Arch Intern Med. 1997 Mar 24;157(6):693-6.
We describe 4 patients with Graves disease who had abnormal increases of serum creatine kinase (CK) concentrations during treatment with antithyroid medications. Three of the patients experienced myalgia and muscle cramps. All of the patients manifested an increase in serum CK levels 1 to 3 months after the administration of antithyroid drugs. Thyrotropin concentrations and cardiac systolic time indexes during the elevation of serum CK concentrations were not consistent with hypothyroidism. The mechanisms are not obvious, but it is likely that the rapid decrease of thyroid hormones in tissues may temporarily cause hypothyroid states, resulting in alterations in CK concentrations. It is suggested that hasty correction of thyrotoxicosis should be avoided in susceptible patients, unless the thyrotoxic conditions are critical.
我们描述了4例格雷夫斯病患者，他们在接受抗甲状腺药物治疗期间血清肌酸激酶（CK）浓度异常升高。其中3例患者出现肌痛和肌肉痉挛。所有患者在服用抗甲状腺药物1至3个月后血清CK水平均升高。血清CK浓度升高期间的促甲状腺激素浓度和心脏收缩时间指数与甲状腺功能减退不一致。其机制尚不清楚，但组织中甲状腺激素的快速下降可能会暂时导致甲状腺功能减退状态，从而导致CK浓度改变。建议对易感患者避免匆忙纠正甲状腺毒症，除非甲状腺毒症情况危急。
