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二尖瓣修复失败后的再次手术。

Reoperation for failure of mitral valve repair.

作者信息

Gillinov A M, Cosgrove D M, Lytle B W, Taylor P C, Stewart R W, McCarthy P M, Smedira N G, Muehrcke D D, Apperson-Hansen C, Loop F D

机构信息

Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, OH 44195, USA.

出版信息

J Thorac Cardiovasc Surg. 1997 Mar;113(3):467-73; discussion 473-5. doi: 10.1016/S0022-5223(97)70359-3.

Abstract

BACKGROUND AND OBJECTIVE

Mitral valve repair is the procedure of choice to correct mitral regurgitation of all types. Up to 10% of patients who undergo mitral valvuloplasty require late reoperation for recurrent mitral valve dysfunction. To determine the causes of failed mitral valve repair, we examined the surgical pathology of patients who underwent reoperation for failed mitral valve repair.

PATIENTS AND RESULTS

From 1986 to 1994, 81 patients had 86 reoperations for recurrent mitral regurgitation after mitral valve repair. Mean age was 59.2 +/- 1.4 years; 55 were men. Primary valve disease was degenerative in 48 patients (59%), rheumatic in 16 (20%), ischemic in 13 (16%), endocarditic in 3 (4%), and congenital in 1 (1%). Mean time interval between initial mitral valve repair and reoperation was 15.6 +/- 2.5 months. Causes of repair failure were procedure-related (50 cases, 58%), valve-related (33 cases, 38%), or unknown (3 cases, 3%). Procedure-related valve failure was caused by suture dehiscence (21 cases), rupture of previously shortened chordae (19 cases), or incomplete initial correction (10 cases). Valve-related repair failure was caused by progressive primary valve disease (27 cases), endocarditis (5 cases), or extensive leaflet retraction (1 case). Repair failure was procedure-related in 70% of patients with degenerative valvular disease versus only 13% of patients with rheumatic valvular disease (p = 0.0001). At reoperation, mitral valve replacement was performed in 64 patients (79%) and repeat mitral valve repair in 17 (21%).

CONCLUSION

We conclude that (1) most mitral valve repair failures are procedure-related in degenerative disease and valve-related in rheumatic disease; (2) rupture of previously shortened chordae is a common cause of late failure in patients with degenerative mitral valve disease; and (3) repeat mitral valve repair results in successful treatment for a minority of patients.

摘要

背景与目的

二尖瓣修复术是纠正各类二尖瓣反流的首选术式。接受二尖瓣成形术的患者中,高达10%的患者因二尖瓣功能障碍复发需要再次手术。为了确定二尖瓣修复失败的原因,我们检查了因二尖瓣修复失败而接受再次手术患者的手术病理情况。

患者与结果

1986年至1994年间,81例患者因二尖瓣修复术后复发性二尖瓣反流接受了86次再次手术。平均年龄为59.2±1.4岁;男性55例。原发性瓣膜疾病中,48例(59%)为退行性病变,16例(20%)为风湿性病变,13例(16%)为缺血性病变,3例(4%)为心内膜炎,1例(1%)为先天性病变。首次二尖瓣修复术与再次手术之间的平均时间间隔为15.6±2.5个月。修复失败的原因与手术相关(50例,58%)、与瓣膜相关(33例,38%)或原因不明(3例,3%)。与手术相关的瓣膜失败是由缝线裂开(21例)、先前缩短的腱索断裂(19例)或初始矫正不完全(10例)引起的。与瓣膜相关的修复失败是由原发性瓣膜疾病进展(27例)、心内膜炎(5例)或广泛的瓣叶回缩(1例)引起的。在退行性瓣膜病患者中,70%的修复失败与手术相关,而在风湿性瓣膜病患者中仅为13%(p = 0.0001)。再次手术时,64例患者(79%)进行了二尖瓣置换术,17例(21%)进行了二尖瓣再次修复术。

结论

我们得出结论:(1)大多数二尖瓣修复失败在退行性疾病中与手术相关,在风湿性疾病中与瓣膜相关;(2)先前缩短的腱索断裂是退行性二尖瓣疾病患者晚期失败的常见原因;(3)二尖瓣再次修复术仅能使少数患者获得成功治疗。

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