Elings V B, Jahn G E, Vogel J H
Circ Res. 1977 Nov;41(5):722-9. doi: 10.1161/01.res.41.5.722.
The isometric tension development of a one-dimensional regionally ischemic muscle was analyzed theoretically. The model consist of a one-dimensional normal segment in series with a one-dimensional ischemic segment. Each segment is modeled as a three-element muscle. The inputs to the various elements, except the contractile element in ischemic segment, were obtained from published data for cat papillary muscles. To be consistent with segment length measurements on ischemic canine hearts, it was assumed that the ischemic contractile element contracted normally at the beginning of contraction and then at some tension, TM, fell behind in its rate of tension development compared to the contractile element in the normal segment. Rate of tension development of various lengths of the ischemic segment and strengths of the ischemic contractile element. At the tension, TM, the ischemic segment begins undergoing paradoxical expansion and, simultaneously, as a result of the expansion. the time derivative of the tension produced by the regionally ischemic muscle exhibits a sudden decrease.
对一维局部缺血肌肉的等长张力发展进行了理论分析。该模型由与一维缺血段串联的一维正常段组成。每个段都被建模为一个三元件肌肉。除缺血段中的收缩元件外，各元件的输入均取自猫乳头肌的已发表数据。为了与缺血犬心脏的节段长度测量结果一致，假设缺血收缩元件在收缩开始时正常收缩，然后在某个张力TM下，其张力发展速率落后于正常段中的收缩元件。研究了缺血段不同长度和缺血收缩元件强度下的张力发展速率。在张力TM时，缺血段开始出现反常扩张，同时，由于这种扩张，局部缺血肌肉产生的张力的时间导数会突然下降。
