Maruyama Y, Fischer R, Bing R J
Jpn Circ J. 1980 Jun;44(6):449-60. doi: 10.1253/jcj.44.449.
The response of the contractile and the series elastic elements to ischemia was studied with isometric contraction and quick release methods after measuring the passive length-tension relationship in glycerinated heart muscle fibers of dogs at resting state. Myocardial infarction was induced by ligating left coronary artery. Muscle fibers taken from the ischemic area three hours after ligation demonstrated reduction in maximal developed tension (P0), the maximal rate of tension development (dp/dtmax) and Vmax. The time to peak tension (t0) was increased. As in fresh papillary muscle the modulus of elasticity of active glycerinated muscle increased in proportion to load. The stiffness of the series elastic element elevated significantly in ischemic muscle fibers. The passive stiffness in resting state showed a decrease in the slope accompanied by an increase in the intercept in ischemic heart muscle. Therefore, increased stiffness of the series elastic element and diminished contractility are present following acute myocardial infarction.
在测量犬甘油化心肌纤维静息状态下的被动长度-张力关系后，采用等长收缩和快速释放方法研究了收缩元件和串联弹性元件对缺血的反应。通过结扎左冠状动脉诱导心肌梗死。结扎后3小时从缺血区域取出的肌纤维显示最大张力发展（P0）、最大张力发展速率（dp/dtmax）和Vmax降低。达到峰值张力的时间（t0）增加。与新鲜乳头肌一样，活性甘油化肌肉的弹性模量与负荷成比例增加。缺血肌纤维中串联弹性元件的刚度显著升高。缺血心肌静息状态下的被动刚度斜率降低，截距增加。因此，急性心肌梗死后存在串联弹性元件刚度增加和收缩力减弱的情况。
