Conry-Cantilena C
Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20892, USA.
Trends Biotechnol. 1997 Feb;15(2):71-6. doi: 10.1016/S0167-7799(97)84206-0.
Infection with hepatitis C virus (HCV) can cause several significant health problems. Sensitive and specific assays for antibodies to HCV are available to identify and confirm individuals infected with HCV. Evaluation of the clinical impact of HCV infection in a patient includes measuring liver biochemistries and possibly liver biopsy. Molecular assays such as HCV genotype identification and qualitative/quantitative HCV RNA analyses may be valuable in considerations of prognosis and therapy. Further refinement of antibody screening and confirmatory assays and standardization of molecular testing are necessary to optimize testing and thus fully characterize the diagnosis of HCV infection.
丙型肝炎病毒（HCV）感染可导致多种严重的健康问题。现已有针对HCV抗体的灵敏且特异的检测方法，用于识别和确认感染HCV的个体。对患者HCV感染的临床影响进行评估包括检测肝脏生化指标，可能还需要进行肝活检。诸如HCV基因型鉴定和定性/定量HCV RNA分析等分子检测方法，在预后和治疗的考量中可能具有重要价值。进一步完善抗体筛查和确证检测以及分子检测的标准化，对于优化检测从而全面表征HCV感染的诊断是必要的。
